HCAR2 (Center) Rabbit Polyclonal Antibody

CAT#: AP52875PU-N

HCAR2 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GPR109A Antibody (Center) in NCI-H292 cell line lysates (35ug/lane).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of Human GPR109A.
  Antigen Region: Amino acids 200-228.
• Specificity: This antibody recognizes Human GRP109A (Center).
  Other species not tested.
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens hydroxycarboxylic acid receptor 2 (HCAR2)
• Database Link:
  Entrez Gene 338442 Human
• Background: NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide
• Synonyms: HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag
• Note: Molecular Weight: 41850 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane