NR0B2 (Center) Rabbit Polyclonal Antibody

CAT#: AP52928PU-N

NR0B2 (Center) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution ELISA: 1/1000.
Western Blot: 1/100 - 1/500.
Immunohistochemistry on paraffin sections:  1/50 - 1/100.
Immunofluorescence: 1/10 - 1/50.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human NR0B2
Specificity This antibody reacts to NR0B2.
Formulation PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% (W/V) sodium azide
Concentration lot specific
Purification Affinity chromatography on Protein A
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Predicted Protein Size 28058 Da
Gene Name Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2)
Background The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Synonyms SHP
Reference Data
Protein Families Druggable Genome, Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.