Mu Opioid Receptor (OPRM1) (Center) Rabbit Polyclonal Antibody

CAT#: AP53000PU-N

Mu Opioid Receptor (OPRM1) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of OPRM1 Antibody (Center) in mouse heart tissue lysates (35ug/lane). OPRM1 (arrow) was detected using the purified Pab.

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with OPRM1 Antibody (Center), which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of OPRM1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

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  Flow cytometry analysis of K562 cells using OPRM1 Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution:

  Western Blot: 1/1000.
  Flow Cytometry: 1/10-1/50.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human, Monkey, Mouse, Porcine, Rat
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 161-187 amino acids from the Center region of human OPRM1
• Specificity: This antibody recognizes Human and Mouse OPRM1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens opioid receptor, mu 1 (OPRM1), transcript variant MOR-1
• Database Link:
  Entrez Gene 18390 MouseEntrez Gene 25601 RatEntrez Gene 574141 MonkeyEntrez Gene 4988 Human
• Background: OPRM1 is the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin (see POMC, MIM 176830) and the enkephalins (see PENK, MIM 131330). The OPRM1 receptor is a membrane of the G protein-coupled receptor family (Bond et al., 1998 [PubMed 9689128]). There are at least 3 types of opioid receptors, mu, kappa (OPRK1; MIM 165196), and delta, each with a distinct pharmacologic profile.
• Synonyms: Mu-type opioid receptor, MOR1
• Note: Molecular Weight: 44779 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction