PABP2 (PABPN1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP53148PU-N

PABP2 (PABPN1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PABPN1 Antibody (C-term) in Hela cell line lysates (35ug/lane). This demonstrates the PABPN1 antibody detected the PABPN1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human PABPN1
• Specificity: This antibody recognizes Human PABPN1 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens poly(A) binding protein nuclear 1 (PABPN1)
• Database Link:
  Entrez Gene 8106 Human
• Background: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.
• Synonyms: PAB2, PABP2, PABP-2, Polyadenylate-binding protein 2
• Note: Molecular Weight: 32749 Da

Reference Data

• Protein Families: Druggable Genome