PDE1B (C-term) Rabbit Polyclonal Antibody

CAT#: AP53233PU-N

PDE1B (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PDE1B Antibody (C-term) in mouse brain tissue lysates (35ug/lane). This demonstrates the PDE1B antibody detected the PDE1B protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with PDE1B Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of Human PDE1B
• Specificity: This antibody recognizes Human and Mouse PDE1B (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: phosphodiesterase 1B
• Database Link:
  Entrez Gene 18574 MouseEntrez Gene 5153 Human
  UniProt ID Q01064
• Background: Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).
• Synonyms: Phosphodiesterase 1B, Phosphodiesterase-1B calmodulin-dependent, Cam-PDE 1B, PDE1B1, PDES1B
• Note: Molecular Weight: 61380 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism