Plakophilin 2 (PKP2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP53319PU-N

Plakophilin 2 (PKP2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Plakophilin-2 Antibody (C-term) in K562 cell line lysates (35ug/lane).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacte with Plakophilin-2 Antibody (C-term), whcih was peroxidase conjugated to the secondary antibody and followed by DAB staining.This data demonstrates the use of PKP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western lot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 837-866 amino acids from the C-terminal region of Human Plakophilin-2
• Specificity: This antibody recognizes Human Plakophilin-2 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens plakophilin 2 (PKP2), transcript variant 2b
• Database Link:
  Entrez Gene 5318 Human
• Background: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
• Synonyms: PKP2
• Note: Molecular Weight: 97415 Da

Reference Data

• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC)