PTPRN2 (N-term) Rabbit Polyclonal Antibody

CAT#: AP53516PU-N

PTPRN2 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in A2058 cell line lysates (35ug/lane) using PTPRN2 antibody. This demonstrates the PTPRN2 antibody detected the PTPRN2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 160-189aa) of human PTPRN2.
• Specificity: This antibody recognizes PTPRN2 at N-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens protein tyrosine phosphatase, receptor type N2 (PTPRN2), transcript variant 1
• Database Link:
  Entrez Gene 5799 Human
• Background: The protein encoded by the PTPRN2 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
• Synonyms: R-PTP-N2, ICAAR, IAR, IA-2beta, Phogrin, KIAA0387
• Note: Molecular Weight: 111271 Da

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Type I diabetes mellitus