RASA1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53583PU-N

RASA1 (C-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

Product Images

Other products for "RASA1"

Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1/1000.
Western Blot: 1/100-1/500.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 965-993 amino acids from the C-terminal region of Human RASA1 / RasGAP.
Specificity This antibody recognizes Human RASA1 / RasGAP (C-term).
Formulation PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens RAS p21 protein activator 1 (RASA1), transcript variant 1
Background
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Synonyms Ras GTPase-activating protein 1, GAP, Ras p21 protein activator, p120GAP, RASA, p120RASGAP
Note Molecular Weight: 116403 Da
Reference Data
Protein Families Druggable Genome
Protein Pathways Axon guidance, MAPK signaling pathway

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.