RBM5 (N-term) Rabbit Polyclonal Antibody

CAT#: AP53614PU-N

RBM5 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RBM5 / LUCA15 Antibody (N-term) in A549 cell line lysates (35ug/lane). This demonstrates the RBM5 antibody detected the RBM5 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of Human RBM5.
• Specificity: This antibody recognizes Human RBM5 (N-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens RNA binding motif protein 5 (RBM5), transcript variant 1
• Database Link:
  Entrez Gene 10181 Human
• Background: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis
• Synonyms: RNA-binding protein 5, NY-REN-9
• Note: Molecular Weight: 92154 Da

Reference Data

• Protein Families: Druggable Genome