RGS14 (Center) Rabbit Polyclonal Antibody

CAT#: AP53650PU-N

RGS14 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of RGS14 Antibody in U937 cell line lysates (35ug/lane). This demonstrates the RGS14 antibody detected the RGS14 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 222-251 amino acids from the Central region of Human RGS14.
• Specificity: This antibody recognizes Human RGS14 (Center).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens regulator of G-protein signaling 14 (RGS14)
• Database Link:
  Entrez Gene 10636 Human
• Background:
  
  

  This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

  
  
• Synonyms: RGS14
• Note: Molecular Weight: 61447 Da

Reference Data

• Protein Families: Druggable Genome