RSK1 p90 (RPS6KA1) Rabbit Polyclonal Antibody

CAT#: AP53743PU-N

RSK1 p90 (RPS6KA1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in K562 cell line lysates (35 ug/lane) using RPS6KA1 Antibody. This demonstrates the RPS6KA1 antibody detected the RPS6KA1 protein (arrow).

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  Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RPS6KA1 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
  Immunohistochemistry: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Recombinant protein from Human RPS6KA1
• Specificity: Recognizes RPS6KA1.
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 2
• Database Link:
  Entrez Gene 6195 Human
• Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Synonyms: Ribosomal S6 kinase 1, 90 kDa ribosomal protein S6 kinase 1, MAPKAPK1A, RSK1, RSK-1, p90RSK1
• Note: Molecular Weight: 82723 Da

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Long-term potentiation, MAPK signaling pathway, mTOR signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation