SEMA4A (N-term) Rabbit Polyclonal Antibody
Other products for "SEMA4A"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1/1,000. Western blotting: 1/100-1/500. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide between 150-180 amino acids from the N-terminal region of Human SEMA4A |
Specificity | Recognizes SEMA4A (N-term). |
Formulation | PBS with 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein A column followed by peptide Affinity purification |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens semaphorin 4A (SEMA4A), transcript variant 2 |
Database Link | |
Background | This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms | Semaphorin-4A, Semaphorin-B, Sema B, SEMAB, SEMB |
Note | Molecular Weight: 83574 Da |
Reference Data | |
Protein Families | Transmembrane |
Protein Pathways | Axon guidance |
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