Smoothened (SMO) (Center) Rabbit Polyclonal Antibody

CAT#: AP53947PU-N

Smoothened (SMO) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

SMO Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SMO antibody detected the SMO protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 538-567 amino acids from the Central region of human SMO
• Specificity: This antibody reacts to SMO.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 86397 Da
• Gene Name: smoothened, frizzled class receptor
• Database Link:
  Entrez Gene 6608 Human
  UniProt ID Q99835
• Background: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
• Synonyms: SMOH, Smoothened homolog

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
• Protein Pathways: Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer