SMURF1 (Center) Rabbit Polyclonal Antibody

CAT#: AP53953PU-N

SMURF1 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

SMURF1 Antibody (Center) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SMURF1 antibody detected the SMURF1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100 - 1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 351-381 amino acids from the Central region of human SMURF1
• Specificity: This antibody reacts to SMURF1.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 86114 Da
• Gene Name: Homo sapiens SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 1
• Database Link:
  Entrez Gene 75788 MouseEntrez Gene 57154 Human
• Background: This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.
• Synonyms: SMURF 1, SMURF-1, KIAA1625

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis