Sorbitol Dehydrogenase (SORD) (Center) Rabbit Polyclonal Antibody

CAT#: AP53985PU-N

Sorbitol Dehydrogenase (SORD) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SORD Antibody (Center) in Hela cell line lysates (35ug/lane).This demonstrates the SORD antibody detected the SORD protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 210-239 amino acids from the Central region of Human SORD.
• Specificity: This antibody recognizes Human SORD (Center).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens sorbitol dehydrogenase (SORD), transcript variant 1
• Database Link:
  Entrez Gene 6652 Human
• Background: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
  

• Synonyms: Sorbitol dehydrogenase
• Note: Molecular Weight: 38325 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Fructose and mannose metabolism, Metabolic pathways