SPR (C-term) Rabbit Polyclonal Antibody

CAT#: AP54030PU-N

SPR (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Sepiapterin reductase (arrow) in mouse liver tissue lysates (35ug/lane) using Sepiapterin reductase / SPR antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 232-261aa) of human Sepiapterin reductase / SPR.
• Specificity: This antibody recognizes Sepiapterin reductase / SPRat N-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) (SPR)
• Database Link:
  Entrez Gene 6697 Human
• Background: The SPR gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiapterin reductase deficiency. A pseudogene has been identified on chromosome 1.
• Synonyms: SDR38C1, EC 1.1.1.153
• Note: Molecular Weight: 28048 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways