Cortactin (CTTN) (N-term) Rabbit Polyclonal Antibody

CAT#: AP54041PU-N

Cortactin (CTTN) (N-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Other products for "CTTN"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution

Immunohistochemistry on Paraffin sections: 1/50-1/100.
Western blot: 1/100-1/500.
Enzyme immunoassay: 1/1000.

Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 16-46aa) of human Cortactin (SRC8)
Specificity This antibody recognizes Cortactin (SRC8) at N-term.
Formulation PBS with 0.09% (W/V) Sodium azide
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a Protein A column followed by peptide affinity purification
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens cortactin (CTTN), transcript variant 1
Background SRC8 (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.
Synonyms CTTN, EMS1, Amplaxin, Oncogene EMS1
Note Molecular Weight: 61586 Da
Reference Data
Protein Families Druggable Genome
Protein Pathways Pathogenic Escherichia coli infection, Tight junction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.