STEAP3 (C-term) Rabbit Polyclonal Antibody

CAT#: AP54071PU-N

STEAP3 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

STEAP3 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the STEAP3 antibody detected the STEAP3 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 440-470 amino acids from the C-terminal region of human STEAP3
• Specificity: This antibody reacts to STEAP3.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 54601 Da
• Gene Name: Homo sapiens STEAP3 metalloreductase (STEAP3), transcript variant 3
• Database Link:
  Entrez Gene 55240 Human
• Background: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
• Synonyms: STEAP-3, Metalloreductase STEAP3, pHyde, Dudulin-2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: p53 signaling pathway