STING (TMEM173) (C-term) Rabbit Polyclonal Antibody

CAT#: AP54275PU-N

STING (TMEM173) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of TM173 Antibody (C-term) in mouse spleen tissue lysates (35 ug/lane). TM173 (arrow) was detected using the purified Pab.

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  TM173 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
  Flow cytometry: 1:10~50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 318~348 amino acids from the C-terminal region of human TM173
• Specificity: This antibody detects TMEM173 / STING (C-term).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens transmembrane protein 173 (TMEM173), transcript variant 1
• Database Link:
  Entrez Gene 72512 MouseEntrez Gene 340061 Human
• Background: Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
• Synonyms: Transmembrane protein 173, MITA
• Note: Molecular Weight: 42193 Da

Reference Data

• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway