Topoisomerase II alpha (TOP2A) (C-term) Rabbit Polyclonal Antibody

CAT#: AP54332PU-N

Topoisomerase II alpha (TOP2A) (C-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1:1;000.
Western blot: 1:100~500.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 1433-1461 amino acids from the C-terminal region of human TOP2A/Topo?.
Specificity This antibody detects TOP2A (C-term).
Formulation PBS with 0.09% (W/V) sodium azide
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Protein A column followed by peptide affinity purification
Storage Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)
Background This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Synonyms TOP2, Top-2, DNA topoisomerase 2-alpha, DNA topoisomerase II alpha isozyme
Note Molecular Weight: 174385 Da
Reference Data
Protein Families Druggable Genome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.