Vitamin D Receptor (VDR) (Center) Rabbit Polyclonal Antibody

CAT#: AP54505PU-N

Vitamin D Receptor (VDR) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

VDR Antibody (Center) western blot analysis in Hela cell line lysates (35 ug/lane). This demonstrates the VDR antibody detected the VDR protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 273-299 amino acids from the Central region of human VDR
• Specificity: This antibody detects Vitamin D3 receptor / NR1I1 (Center).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR), transcript variant 1
• Database Link:
  Entrez Gene 7421 Human
• Background: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
• Synonyms: VDR, 1,25-dihydroxyvitamin D3 receptor
• Note: Molecular Weight: 48289 Da

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors