HIST4H4 (Citrulline R3) Rabbit Polyclonal Antibody

CAT#: AP55009SU-N

HIST4H4 (Citrulline R3) rabbit polyclonal antibody, Serum

Product Images

Conrtol of the specificity of anti H4-Cit3 using H4Cit3 peptide, H4-Arg3 peptide and H3Cit2, 8, 17 peptide

Specifications

Product Data

• Applications: Assay, ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/5000 - 1/10000.
  Immunohistochemistry: 1/100 - 1/1000.
  Western Blot: 1/100 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from N-term region of Human Histone H4, containing Citrulline at position 3
• Specificity: This antibody reacts with Histone H4 Citrulline at the position 3 (10 kDa). No cross reaction with free H4 or with other citrullinated proteins.
• Formulation: State: Serum
  State: Lyophilized serum
• Reconstitution Method: Restore in distilled water.
• Database Link:
  Entrez Gene 121504 Human
• Background: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
• Synonyms: HIST1H4, H4/A, H4FA