c Maf (MAF) Rabbit Polyclonal Antibody

CAT#: AP55068SU-N

c Maf (MAF) rabbit polyclonal antibody, Serum

Product Images

Recombinant Maf-GST protein

Specifications

Product Data

• Applications: ELISA, EMSA, IHC, WB
• Recommended Dilution: ELISA.
  Western Blot: 1/200-1/5000.
  Immunohistochemistry: 1/50-1/500.
  Useful for Electrophoretic Mobility Shift Assay (EMSA).
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Maf-GST fusion protein
• Specificity: This antibody reacts with 47 kDa Maf protein derived from a transfected CEF cell line.
• Formulation: State: Serum
  State: Lyophilized serum
• Reconstitution Method: Restore in distilled water.
• Storage:

  Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Database Link:
  Entrez Gene 4094 Human
• Background: c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
• Synonyms: Transcription factor Maf, Proto-oncogene c-maf, V-maf