c Maf (MAF) Rabbit Polyclonal Antibody

CAT#: AP55068SU-N

c Maf (MAF) rabbit polyclonal antibody, Serum


USD 450.00

5 Weeks*

Size
    • 200 ul

Product Images

Specifications

Product Data
Applications ELISA, EMSA, IHC, WB
Recommended Dilution ELISA.
Western Blot: 1/200-1/5000. 
Immunohistochemistry: 1/50-1/500.
Useful for Electrophoretic Mobility Shift Assay (EMSA).
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Maf-GST fusion protein
Specificity This antibody reacts with 47 kDa Maf protein derived from a transfected CEF cell line.
Formulation State: Serum
State: Lyophilized serum
Reconstitution Method Restore in distilled water.
Storage

Prior to reconstitution store at -20°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Background c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
Synonyms Transcription factor Maf, Proto-oncogene c-maf, V-maf
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.