CD41-CD61 Complex Mouse Monoclonal Antibody [Clone ID: P2]

CAT#: BM2543F

CD41-CD61 Complex mouse monoclonal antibody, clone P2, FITC

Specifications

Product Data

• Clone Name: P2
• Applications: FC
• Recommended Dilution: Flow Cytometry: 20 µl/5 x 10⁵ platelets/test.
  A wash is required to yield optimal results. Bring reagent to 20-25°C prior to use.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human platelets. Hybridization of Sp2/0-Ag14 myeloma cells with spleen cells from Balb/c mice.
• Specificity: This antibody reacts to CD41. The molecular weight of the recognized antigen is 135-95kDa.
  Reacts with gpIIb in the intact complex with gpIIIa, but not with gpIIb or gpIIIa, separately.
  Inhibits platelet aggregation induced by thrombin, collagen and ADP.
• Formulation: PBS, pH 7.2
  Label: FITC
  State: Liquid purified IgG fraction
  Stabilizer: 2 mg/ml BSA
  Preservative: 0.09% Sodium Azide
  Label: Fluorescein
• Purification: Ion Exchange or Affinity Chromatography
• Conjugation: FITC
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitve and should protected from light.
• Stability: Shelf life: one year from despatch.
• Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
• Synonyms: GPIIb-IIIa, ITGA2B, GP2B, ITGAB, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, GP3A, CD41, CD61, Integrin alpha-IIb, Integrin beta-3, ITGB3