Epstein Barr Virus / EBV Early Antigen-D Mouse Monoclonal Antibody [Clone ID: 261]
CAT#: BM3118
Epstein Barr Virus / EBV Early Antigen-D mouse monoclonal antibody, clone 261, Purified
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Specifications
Product Data | |
Clone Name | 261 |
Applications | IF, WB |
Recommended Dilution | Suitable for use in IFA, Western blot, and Immunohistochemistry (weak, antigen retrieval required). |
Host | Mouse |
Isotype | IgG2 |
Clonality | Monoclonal |
Immunogen | Recombinant EB early antigen-diffuse. |
Specificity | This antibody is specific for the "Early antigen-diffuse" (EA-D) 50-52 kD of EBV. |
Formulation | 0.01M PBS, pH 7.2 containing 0.09% Sodium Azide as preservative and no stabilizers. State: Purified State: Liquid purified Ig fraction (> 90% pure). |
Concentration | lot specific |
Purification | Protein A Chromatography. |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Background | EBV is a human herpesvirus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. |
Synonyms | HHV4, HHV-4 |
Reference Data |
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