HCV Core protein (1-80) Mouse Monoclonal Antibody [Clone ID: 6A1]

CAT#: BM3254F

HCV Core protein (1-80) mouse monoclonal antibody, clone 6A1, FITC


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 6A1
Applications ELISA, IF, IHC
Recommended Dilution ELISA employing native viral lysates.
Immunofluorescence.
Immunohistochemistry on Frozen Sections only.
Does not work in Western blot.
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant protein.
Specificity HCV core antigen.
Recognizes 1-80 amino acid residues of HCV core antigen.
Formulation 1 x PBS, pH 7.2 containing 0.01% Sodium Azide as preservative.
Label: FITC
State: Liquid purified Ig fraction.
Label: Highly purified Isomer I of Fluorescein Isothiocyanate Care is taken to ensure complete removal of any free fluorescein from the final product
Concentration lot specific
Purification Protein A Chromatography
Conjugation FITC
Storage Store the antibody at 2-8°C for 2 months or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background The Hepatitis C Virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication.
Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Synonyms Hepatitis C Virus core protein
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.