Desmoplakin (DSP) (DP1+DP2) Mouse Monoclonal Antibody [Clone ID: DP2.15]

CAT#: BM371

Desmoplakin (DSP) (DP1+DP2) mouse monoclonal antibody, clone DP2.15, Purified


USD 360.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Clone Name DP2.15
Applications IF, IHC, WB
Recommended Dilution Immunoblotting.
Immunofluorescence.
Immunohistochemistry on Frozen Sections:
Dilute 1/10 with PBS, pH 7.4 
Incubation Time: 1 h at RT.
Reactivities Amphibian, Bovine, Canine, Chicken, Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Bovine Desmoplakin 1 and 2
Specificity This antibody reacts to Desmoplakin 1&2.
It shows distinct punctate membrane staining of different epithelia.
Tumors Specifically Detected: Primary and metastatic carcinoma and meningioma.
Polypeptides Reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000).
Reactivity on Tested Cell Lines: Several Human carcinoma cell lines: MCF-7, A-431; Rat MHC1C1 cell line; Bovine cells: MDBK, BMGE.
Formulation Final solution contains PBS, pH 7.4
State: Purified
State: Lyophilized purified Ig fraction
Stabilizer: 0.5% BSA
Preservative: 0.09% Sodium Azide
Reconstitution Method Restore in 1 ml distilled water
Purification Affinity Chromatography on Protein A
Storage

Prior to reconstitution store at 2-8°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens desmoplakin (DSP), transcript variant 2
Background Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Synonyms DP, DSP, 250/210 kDa paraneoplastic pemphigus antigen
Reference Data
Protein Families Druggable Genome
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.