CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: MEM-05]

CAT#: BM4047APC

CD31 (PECAM1) mouse monoclonal antibody, clone MEM-05, APC


USD 300.00

2 Weeks*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name MEM-05
Applications FC
Recommended Dilution Flow Cytometry analysis of Human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. 
The content of a vial (1 ml) is sufficient for 100 Tests.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Leukocytes of patient suffering from LGL-type leukaemia
Specificity The antibody MEM-05 reacts with CD31 (PECAM-1), a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
Formulation PBS
Label: APC
State: Liquid purified Ig fraction
Preservative: 15 mM Sodium Azide
Label: Conjugated with cross-linked Allophycocyanin under optimum conditions
Purification Size-Exclusion Chromatography
Conjugation APC
Storage Store the antibody in the dark at 2-8°C.
Do Not Freeze!
Avoid prolonged exposure to light.
Stability Shelf life: One year from despatch.
Gene Name platelet and endothelial cell adhesion molecule 1
Background CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in rebulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Synonyms PECAM-1, EndoCAM, GPIIA'
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.