Tfrc Rat Monoclonal Antibody [Clone ID: ER-MP21]

CAT#: BM4087F

Tfrc rat monoclonal antibody, clone ER-MP21, FITC

Specifications

Product Data

• Clone Name: ER-MP21
• Applications: FC, FN, IHC
• Recommended Dilution: Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50.
  Flow cytometry: The typical starting working dilution is 1:50.
  Functional assays (inhibition of biological activity).
  Does not work in Immunohistochemistry on paraffin sections.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody detects CD71.
• Formulation: PBS
  Label: FITC
  State: Lquid 0.2 µm filtered Ig fraction
  Stabilizer: 1% bovine serum
• Concentration: 0.1 mg/ml
• Purification: Protein G
• Conjugation: FITC
• Database Link:
  Entrez Gene 22042 Mouse
• Background: CD71 is a 200 kDa glycoprotein composed of two identical, disulfide-linked chains. Each chain is capable of binding transferrin, an iron-transport molecule. Binding of transferrin to its receptor followed by endocytosis of the receptor-ligand complex is a major cellular iron-uptake mechanism. Iron uptake by the proliferating cell is essential for the iron-containing enzyme ribonucleotide reductase involved with DNA synthesis. CD71 is not only expressed by cycling cells, but also by cells that require iron for other iron-dependent proteins, such as the enzyme peroxidase in monocytes. Rapidly proliferating cells, as in malignancy, generally express CD71 abundantly. Furthermore, CD71 has been described as a marker of immature, proliferating T cells.
• Synonyms: TfR1, p90, Transferrin receptor protein 1