Calca Goat Polyclonal Antibody

CAT#: BP022

Calca goat polyclonal antibody, Purified

Product Images

Figure 1. Paraffin embedded rat intestine stained with goat anti Rat CGRP antibody.

Specifications

Product Data

• Applications: ELISA, IF, IHC
• Recommended Dilution: ELISA: 1/500-1/2500.
  Immunofluorescence.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections.
• Reactivities: Guinea Pig, Mouse, Reptiles, Rat
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic Rat Tyr-CGRP (23-37) conjugated to gamma Globulin
• Specificity: Recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and may play a role in migraine.
  This antibody is reactive with both whole molecule (1-37) and the C-terminal fragment (23-37).
  Specifically visualises CGRP in brain cells.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Database Link:
  Entrez Gene 24241 Rat
• Background: CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
• Synonyms: Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I
• Note: The antibody has been described to work with reptilian material.