Apolipoprotein A I / APO AI Rabbit Polyclonal Antibody

CAT#: BP2052

Apolipoprotein A I / APO AI rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: ID, Ie, RID, WB
• Recommended Dilution: Radial Immunodiffusion.
  Immuno Double-Diffusion.
  Rocket IEP.
  Western blot (Immunoblotting).
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Purified Mouse Apolipoprotein AI from mouse plasma high density lipoprotein.
• Specificity: This antibody is specific for Mouse Apolipoprotein A1 (Apo A1).
  Extremely low recognition of Human Apo A1.
• Formulation: State: Serum
  State: Liquid Neat Serum (heat inactivated and 0.22µm filtered)
  Preservative: 0.025% Sodium Azide
• Concentration: lot specific
• Storage: Upon receipt, store (in aliquots) at -20°C to -80°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease.
  The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
• Synonyms: APOA1, ApoA-I, Apo-AI, ApoAI