Complement C5 (C5) Sheep Polyclonal Antibody

CAT#: BP373

Complement C5 (C5) sheep polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: ID, IHC
• Recommended Dilution: Immunohistochemistry: 1/20-1/200 (as a guide).
  Immunodiffusion.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Human C5 purified from plasma
• Specificity: Gives a single arc when tested by IEP against fresh Human plasma.
  Identity has been confirmed by Double Diffusion against fresh Human plasma and a known anti-Human C5.
• Formulation: Glycine buffered saline, pH 7.4, 0.1% EACA, 0.01% Benzamidine and 1mM EDTA
  State: Ig Fraction
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Purification: Ion Exchange Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement C5 (C5), transcript variant 1
• Database Link:
  Entrez Gene 727 Human
• Background: C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa).
  C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain).
• Synonyms: CPAMD4, Complement component 5

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus