Cortisol Donkey Polyclonal Antibody

CAT#: BP393

Cortisol donkey polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, R
• Recommended Dilution: ELISA: 1/100.
  Radioimmunoassays: 1/100.
• Reactivities: Human
• Host: Donkey
• Clonality: Polyclonal
• Immunogen: Cortisol-3-(Ocarboxymethyl)oxime-BSA.
• Specificity: This antibody recognizes the Glucocorticoid Hormone Cortisol, that is produced in the adrenal cortex and is involved in responses to stress.
  Cross Reactivities of this antibody:
  Cortisol: 100%
  Prednisolone: 38%
  11-Deoxycortisol: 2.5%
  17a-OHP: 0.4%
  Corticosterone: < 0.1%
  Cortisone: 23%
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Background: Cortisol is the most potent glucocorticoid produced by the human adrenal.
  It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
• Synonyms: Hydrocortisone
• Note: 1. Johansen, I.B. et al. (2011) Cortisol response to stress is associated with myocardial remodeling in salmonid fishes. J Exp Biol. 214: 1313-21.