Complement C3 (C3) (neoepitope) Chicken Polyclonal Antibody

CAT#: BP4009

Complement C3 (C3) (neoepitope) chicken polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA: The titer with native Human C3a was 1/5000.
• Reactivities: Human
• Host: Chicken
• Clonality: Polyclonal
• Immunogen: Peptide coupled to carrier protein.
  The antibody was generated against the carboxy-terminal neoepitope which is not exposed on C3, allowing discrimination between C3 and C3a.
• Specificity: This antibody reacts with Human C3a and C3adesArg (67-76).
  It does not cross-react with C3 or C4a.
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified IgY fraction
  Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: Six months from despatch.
• Gene Name: Homo sapiens complement component 3 (C3)
• Database Link:
  Entrez Gene 718 Human
• Background: The complement system is part of the innate immune system representing humoral defence. Activation of the complement cascade via the classical, the alternative or the Lectin pathway liberates several biologically active by-products, among them the anaphylatoxin C3a. Measurement of C3a (and C4a) in plasma or other body fluids can yield important clues about the pathological, and particularly also the inflammatory status of an organism. In serum, C3a activity is under strict control of the carboxypeptidase N. This enzyme rapidly cleaves the C-terminal arginine, thereby generating C3adesArg which shows greatly reduced biological activity as compared to C3a. Thus, the biological activity of C3a is focused mainly on its point of generation, while the degradation product C3adesArg remains relatively stable until it is cleared from the circulation.
• Synonyms: CPAMD1, Complement component 3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus