SQSTM1 (C-term) Guinea Pig Polyclonal Antibody

CAT#: BP5002

SQSTM1 (C-term) guinea pig polyclonal antibody, Serum

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blotting: 1/1000-1/2000 (ECL).
  Immunohistochemistry on Frozen Sections: 1/100-1/600.
  Immunohistochemistry on Paraffin Embedded Sections: 1/100-1/600 (microwave pretreatment improves staining).
  Incubation time: 1h at RT, extended with paraffin material.
• Reactivities: Human, Mouse, Rat
• Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: C-terminal domain (20 amino acids: C-NYD IGA ALD TIQ YSK HPP PL) of Human p62 protein, coupled to KLH.
• Specificity: This antibody reacts with Human 62 kD (p62) protein, present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. p62 protein (also described as ubiqutin-binding protein; sequestosome 1, SQSTM1) has been found in many tissues and cells, including lymphoid cells, serving probably a common cellular signal transduction mechanism (e.g. ubiquitin-associated degradation and autophagy).
  The antiserum stains also neurofibrillary tangles in the brain of patients suffering from Alzheimer's disease.
• Formulation: State: Serum
  State: Liquid Stabilized Antiserum
  Preservative: 0.09% Sodium Azide
• Gene Name: Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2
• Database Link:
  Entrez Gene 18412 MouseEntrez Gene 113894 RatEntrez Gene 8878 Human
• Synonyms: Sequestosome-1, EBIAP, ORCA, OSIL, p60, p62

Reference Data

• Protein Families: Druggable Genome, Transcription Factors