delta 2 Catenin (CTNND2) (1175-1192) Guinea Pig Polyclonal Antibody

CAT#: BP5027

delta 2 Catenin (CTNND2) (1175-1192) guinea pig polyclonal antibody, Serum

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunoblotting: 1/2500 for Wesern blot using ECL.
  Immunofluorescence Microscopy: 1/100.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections (only after microwave treatment).
  Positive Control: Murine brain, retina.
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide J7 (corresponding to aa 1175-1192), coupled to KLH
• Specificity: The antibody reacts specifically with Neurojungin (Delta-Catenin, a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Delta-Catenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimers disease.
  No cross-reaction with other members of the armadillo / Plakoglobin protein family.
  Tested Reactivities on Cultured Cell Lines: Murine cell line A1B2, stably transfected with Neurojungin cDNA.
• Formulation: State: Serum
  State: Whole Antiserum
  Preservative: 0.09% Sodium Azide
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1501 Human
• Background: Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta-Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimers disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co-localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development.
• Synonyms: CTNND2, NPRAP, Delta-catenin, Neurojungin, GT24