Noggin (NOG) Mouse Monoclonal Antibody [Clone ID: OTI1H8]

CAT#: CF500029

Carrier-free (BSA/glycerol-free) Noggin mouse monoclonal antibody, clone OTI1H8 (formerly 1H8)

Formulation: Standard Carrier Free


  View other "OTI1H8" antibodies (2)

USD 465.00

In Stock*

Size
    • 100 ug

Specifications

Product Data
Clone Name OTI1H8
Applications IF, IHC, WB
Recommended Dilution WB 1:20000~40000, IHC 1:50, IF 1:100
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 28-232 of human noggin (NP_005441) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 23.7 kDa
Gene Name Homo sapiens noggin (NOG), mRNA.
Background Noggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Synonyms SYM1; SYNS1; SYNS1A
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways TGF-beta signaling pathway

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