Carbonic Anhydrase IX (CA9) Mouse Monoclonal Antibody [Clone ID: OTI1G7]

CAT#: CF500623

Carrier-free (BSA/glycerol-free) CA9 mouse monoclonal antibody, clone OTI1G7 (formerly 1G7)

Formulation: Standard Carrier Free


  View other "OTI1G7" antibodies (2)

USD 465.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI1G7
Applications FC, IHC, WB
Recommended Dilution WB 1:2000, IHC 1:50, Flow 1:100
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human CA9 expression vector
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 49.7 kDa
Gene Name Homo sapiens carbonic anhydrase 9 (CA9), mRNA.
Background Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-basebalance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Synonyms CAIX; MN
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Nitrogen metabolism

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