APE1 (APEX1) Mouse Monoclonal Antibody [Clone ID: OTI1H9]

CAT#: CF800330

Carrier-free (BSA/glycerol-free) APEX1 mouse monoclonal antibody, clone OTI1H9 (formerly 1H9)

Formulation: Standard Carrier Free


  View other "OTI1H9" antibodies (2)

USD 465.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI1H9
Applications IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivities Human, Monkey, Mouse, Rat, Dog
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-242 of human APEX1 (NP_001632) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 35.4 kDa
Gene Name Homo sapiens apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1), transcript variant 1, mRNA.
Background Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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