bcl 6 (BCL6) Mouse Monoclonal Antibody [Clone ID: OTI1C3]

CAT#: CF804186

Carrier-free (BSA/glycerol-free) BCL6 mouse monoclonal antibody,clone OTI1C3

Product Images

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

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  Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

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  Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

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  Immunohistochemical staining of paraffin-embedded Human Ovary tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-BCL6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3min, TA804186) (1:150)

• Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-BCL6 mouse monoclonal antibody. (TA804186) (1:150)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human bladder tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-BCL6 mouse monoclonal antibody. (TA804186)

• Immunohistochemical staining of paraffin-embedded Human tonsil using anti-BCL6 mouse monoclonal antibody. (TA804186)

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Specifications

Product Data

• Clone Name: OTI1C3
• Applications: IHC
• Recommended Dilution: IHC 1:150
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1-300 of human BCL6 (NP_001697) produced in E.coli.
• Formulation: Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
• Reconstitution Method: For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Homo sapiens BCL6 transcription repressor (BCL6), transcript variant 1, mRNA.
• Database Link:
  NP_001697
  Entrez Gene 12053 MouseEntrez Gene 303836 RatEntrez Gene 604 Human
  UniProt ID P41182
• Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

Reference Data

• Protein Families: Druggable Genome, Transcription Factors