Cryptochrome I (CRY1) Mouse Monoclonal Antibody [Clone ID: OTI2C10]

CAT#: CF809886

Carrier-free (BSA/glycerol-free) CRY1 mouse monoclonal antibody,clone OTI2C10

Formulation: Standard Carrier Free


  View other "OTI2C10" antibodies (2)

USD 465.00

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Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI2C10
Applications WB
Recommended Dilution WB 1:2000
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 502-584 of human CRY1(NP_004066) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 66.2 kDa
Gene Name Homo sapiens cryptochrome circadian regulator 1 (CRY1), mRNA.
Background This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Synonyms PHLL1
Reference Data
Protein Families Druggable Genome
Protein Pathways Circadian rhythm - mammal

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