Serotonin N acetyltransferase (AANAT) Mouse Monoclonal Antibody [Clone ID: OTI3B9]

CAT#: CF810171

Carrier-free (BSA/glycerol-free) AANAT mouse monoclonal antibody,clone OTI3B9

Formulation: Standard Carrier Free


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USD 465.00

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Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI3B9
Applications WB
Recommended Dilution WB 1:2000
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-72 of human AANAT (NP_001079) produced in E.coli.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 23.2 kDa
Gene Name Homo sapiens aralkylamine N-acetyltransferase (AANAT), transcript variant 2, mRNA.
Background The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms DSPS; SNAT
Reference Data
Protein Pathways Metabolic pathways, Tryptophan metabolism

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