PTPN22 Mouse Monoclonal Antibody [Clone ID: OTI6B1]
CAT#: CF810177
Carrier-free (BSA/glycerol-free) PTPN22 mouse monoclonal antibody,clone OTI6B1
Other products for "PTPN22"
Specifications
Product Data | |
Clone Name | OTI6B1 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:1000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 (NP_057051) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 91.5 kDa |
Gene Name | Homo sapiens protein tyrosine phosphatase non-receptor type 22 (PTPN22), transcript variant 1, mRNA. |
Database Link | |
Background | This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] |
Synonyms | LYP; LYP1; LYP2; PEP; PTPN8 |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase |
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