CD1 (CD1A) Mouse Monoclonal Antibody [Clone ID: 201B5.08]

CAT#: DDX0081A546-100

CD1 (CD1A) mouse monoclonal antibody, clone 201B5.08

Product Images

IHC staining of human skin frozen section with clone 201B5 (DDX0081)

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  Surface FACS analysis of CD1a expression on CD34+-derived DCs (day 12 of culture)

Specifications

Product Data

• Clone Name: 201B5.08
• Applications: FC
• Recommended Dilution: DDX0081A488-50 / DDX0081A488-100 Alexa-fluor®488: Surface flow cytometry, IF.
  DDX0081A546-50 / DDX0081A546-100 Alexa- fluor®546 (on request): surface Flow Cytometry.
  DDX0081A647-50 /DDX0081A647-100 Alexa- fluor®647: Surface flow cytometry.
  
• Reactivities: Human, Porcine
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: in vitro derived human DCs (GMCSF + TNFα)
• Specificity: Human CD1a (epitope in extracellular domain).
  Species cross- reactivity: Pig.
• Formulation: Label: Alexa Fluor 546
• Concentration: lot specific
• Purification: QMA hyper D ion exchange chromatography
• Conjugation: Alexa Fluor 546
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing
• Gene Name: CD1a molecule
• Database Link:
  Entrez Gene 909 Human
  UniProt ID P06126
• Background: CD1 family molecules have structural homologies with MHC class I molecules. They are monomorphic proteins of 50 kDa, non-covalently associated with Beta-2-microglobulin. Human CD1a molecules are divided in 2 groups. Group 1 includes CD1a, CD1b, and CD1c, while group 2 consists of the CD1d molecule. CD1a is mainly expressed at the cell-surface and in recycling vesicles. CD1a occurs in Birbeck granules of Langerhans cells and plays a role in presentation of non-peptide antigens. CD1a is expressed in vitro on CD34⁺-generated DCs and on monocyte-derived DCs. (Burdin N. et al., 1999, Curr Opin Immunol, 11:326-31).
• Synonyms: T6/Leu-6, hTa1