CD21 (CR2) (CD21L) Mouse Monoclonal Antibody [Clone ID: 7D6]

CAT#: DDX0120P-100

CD21 (CR2) (CD21L) mouse monoclonal antibody, clone 7D6

Product Images

mAb 7D6 staining on FDC clusters. Slides were incubated with mAb 7D6 and subsequently with a sheep anti-mouse IgG1. The binding of antibody was revealed using APAAP method and developed by Fast red substrate.

• 

  Giemsa staining of isolated FDCs clusters.

Specifications

Product Data

• Clone Name: 7D6
• Applications: IHC
• Recommended Dilution: IHC frozen section.
  Usage recommendation: *This monoclonal antibody may be used between 1-15 μg/ml.
  
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: enriched-human tonsillar FDCs (follicular dendritic cells)
• Specificity: human follicular dendritic cells
• Formulation: State: Purified
  State: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
• Gene Name: complement component 3d receptor 2
• Database Link:
  Entrez Gene 1380 Human
  UniProt ID P20023
• Background: An antibody has been generated that specifically recognizes human follicular dendritic cells (FDCs) on the long CR2 / CD21L isoform (CD21L). Follicular dendritic cells represent a cell-type ontogenetically distinct from all other Dendritic Cells (DCs). They are found within B lymphocyte follicles of secondary lymphoid tissue. At the opposite, B lymphocytes selectively express the short CR2 / CD21 lacking exon 10a (CD21S). mAb 7D6 does not recognize CD21 expressed on other cells. (Liu Y.J. et al, 1997; J. Exp. Med.185: 165-170)
• Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker