LAMP3 Mouse Monoclonal Antibody [Clone ID: 104G4]

CAT#: DDX0190B-100

LAMP3 mouse monoclonal antibody, clone 104G4

Product Images

IHC staining of human lung frozen section with clone 104G4 (DX0190)

Specifications

Product Data

• Clone Name: 104G4
• Applications: FC, IHC
• Recommended Dilution: Intracyto Flow cytometry, IHC
• Reactivities: Human, Sheep
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: human DC-LAMP alkaline phosphatase fusion protein
• Specificity: human DC-LAMP (epitope in intracytoplasmic domain).
  Species cross-reactivity: sheep.
• Formulation: Label: Biotin
  State: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol
• Concentration: lot specific
• Conjugation: Biotin
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: lysosomal associated membrane protein 3
• Database Link:
  Entrez Gene 27074 Human
  UniProt ID Q9UQV4
• Background: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
  (de Saint-Vis B et al, 1998 ; Immunity ; 9:325-336)
• Synonyms: DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker