LAMP3 Rat Monoclonal Antibody [Clone ID: 1010E1.01]

CAT#: DDX0191P-100

LAMP3 rat monoclonal antibody, clone 1010E1.01

Product Images

IHC staining of human lymph node paraffin section with clone 1010E1 (DX0191)

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  IHC staining of canine tissues

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  IHC on mouse lung cryosection

Specifications

Product Data

• Clone Name: 1010E1.01
• Applications: IHC
• Recommended Dilution: IHC paraffin (formol, Bouin) in human
• Reactivities: Canine, Feline, Human, Mouse, Sheep
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: recombinant murine DC LAMP
• Specificity: murine DC-LAMP (epitope in intracytoplasmic domain).
  Species cross-reactivity: human, cat, dog, sheep, mouse.
• Formulation: Tris-NaCl pH 8
  State: Purified
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  
• Gene Name: lysosomal associated membrane protein 3
• Database Link:
  Entrez Gene 27074 Human
  UniProt ID Q9UQV4
• Background: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
  (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
• Synonyms: DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker