Lamp3 Rat Monoclonal Antibody [Clone ID: 1006F7.05]

CAT#: DDX0192A546-100

Lamp3 rat monoclonal antibody, clone 1006F7.05


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 1006F7.05
Applications FC, IF
Recommended Dilution DDX0192P-50 / DDX0192P-100 Purified: Surface and Intra Flow cytometry, IHC, IF. 
DDX0192A488-50 / DDX0192A488-100 Alexa-fluor®488: Surface and Intra Flow cytometry, IF.
DDX0192A546-50 / DDX0192A546-100 Alexa- fluor®546: Surface and Intra Flow cytometry.
DDX0192A647-50 / DDX0192A647-100 Alexa- fluor®647: Surface and Intra Flow cytometry.
DDX0192B-50 / DDX0192B-100: Biotin (on request): Surface and Intra Flow cytometry, IHC. 
Usage recommendation:
*This monoclonal antibody may be used between 5-20μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen recombinant murine DC-LAMP
Specificity Murine DC-LAMP
Species cross-reactivity: none.
Formulation Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol
Label: Alexa Fluor 546
Concentration lot specific
Purification QMA hyper D ion exchange chromatography
Conjugation Alexa Fluor 546
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name lysosomal-associated membrane protein 3
Background The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in the mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. DC-LAMP is specifically expressed by human DCs upon activation. However, its mouse counterpart has not be detected in mature DCs. DC-LAMP is constitutively expressed by mouse. Confocal and immunoelectron microscopy have shown that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contains lung surfactant protein B.
(Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619-29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71 ; Rochereau N et al, Vaccine, 2011).
Synonyms DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.