DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: 109H12.03]

CAT#: DDX0207A488-100

DC SIGN (CD209) mouse monoclonal antibody, clone 109H12.03

Product Images

IF staining of L-SIGN-transfected cells with 109H12.03.

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  PFA or acetone fixed murine intestine cryosections stained with 109H12 (Rachereau N et al, Vaccine 2011).

Specifications

Product Data

• Clone Name: 109H12.03
• Applications: FC, IF, IHC
• Recommended Dilution: Surface Flow cytometry, IHC, IF
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Human DC-SIGN-transfected HeLa cells.
• Specificity: Human DC-SIGN.
  Species cross- reactivity: L-SIGN, Mouse DC-SIGN
• Formulation: PBS 50% glycerol
  Label: Alexa Fluor 488
• Concentration: lot specific
• Conjugation: Alexa Fluor 488
• Storage: Aliquot storage conditions -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: CD209 molecule
• Database Link:
  Entrez Gene 30835 Human
  UniProt ID Q9NNX6
• Background: DC-SIGN (“DC Specific, ICAM-3 Grabbing, Nonintegrin”)/CD209 and liver/lymph node-specific ICAM-3-grabbing nonintegrin (L-SIGN) (CD299/DC-SIGNR for DC-SIGN-related molecule; DC-SIGN2) are closely related genes that map to chromosome 19p13.3. Both genes encode a member of the C-type lectin family of type II transmembrane proteins. The two receptors are 77% identical at the amino acid level, have similar ligands. They are expressed in different tissues. Both receptors have been shown to interact with ICAM-3 DC-SIGN is a high affinity receptor for HIV gp120 (Soilleux EJ. 2003, Clinical Science 104, 437-; Dakappagari N., et al. 2006, The J Immunol, 176, 426; Geijtenbeeck T.B., et al. 2000, Cell, 100, 57 ; .Bashirova A. et al., 2001, J.Exp. Med., 193, 671 ; Canard B et al, Immunol Lett. 2011, 135(1-2):165-72 ; Rochereau N. et al, Vaccine 201; Kwan WH et al, PLoS Negl.Trop.Dis, 2:e311, 2008).
• Synonyms: DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker