IL17 (IL17A) Mouse Monoclonal Antibody [Clone ID: 408H6.01]

CAT#: DDX0336P-100

IL17 (IL17A) mouse monoclonal antibody, clone 408H6.01


USD 440.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 408H6.01
Applications ELISA, FC, NEUT, WB
Recommended Dilution DDX0336P-50 DDX0336P-100 Purified: ELISA capture, FACS intracellular, Neutralization, Western Blot.
DDX0336B-50 DDX0336B-100 Biotin: ELISA Detection, Western Blot. 

Usage recommendation:

*This monoclonal antibody may be used between 1-10 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Reactivities Human, Mouse
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen rhCytotoxic T Lymphocyte associated-Antigen 8 transfected COS-7 cells.
Specificity Human IL-17A. 
Species cross-reactivity: Mouse.
Formulation Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8.
Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles. 
Coupled antibodies: glycerol protects from freezing.
Gene Name interleukin 17A
Background IL-17 (cytotoxic T lymphocyte associated antigen 8) is a CD4+ T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. To address a possible mechanism by which IL-17 may promote alloreactivity, we examined the influence of IL-17 on the differentiation and function of bone marrow-derived cells propagated in GM-CSF with or without IL-4 to promote dendritic cell (DC) growth. A minor proportion of CD11c+ DC expressed the IL-17R. IL-17 promoted the maturation of DC progenitors, as evidenced by increased cell surface expression of CD11c, costimulatory molecules (CD40, CD80, CD86), and MHC class II Ag, and allostimulatory capacity. IL-17 had a lesser effect on the phenotype and function of more fully differentiated myeloid DC. These findings suggest a role for IL-17 in allogeneic T cell proliferation that may be mediated in part via a maturation-inducing effect on DC. IL-17 appears to be a novel target for therapeutic intervention in allograft rejection. hIL17 stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and G-CSF and PGE2. (Fossiez F et al, 1996 ; J. Exp. Med., 183:2593-2603 ; Fossiez F. et al, 1998 ; Int. Rev. Immunol., 16:541-551).
Synonyms IL-17A, IL17, IL-17, CTLA8, CTLA-8
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.